| ncRNA name | hsa_circ_0001649 |
| ncRNA Category | circRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB samples and normal retina samples; human RB cell lines WERI-RB1, Y79, SO-Rb50 and HXO-RB44; human RPE cell line ARPE-19 |
| Methods | qRT-PCR, CCK-8 assay, colony formation assay, flow cytometry, caspase-3/9 activity assay, Western blot, xenograft, immunohistochemistry |
| Expression pattern | down-regulated |
| Functional description | The downregulation of hsa_circ_0001649 was associated with larger tumor size and advanced intraocular international retinoblastoma classify (IIRC) stage in RB patients.Hsa_circ_0001649 inhibits cell growth and promotes cell apoptosis in RB cells. AKT/mTOR signaling pathway is involved in the cell growth alteration affected by hsa_circ_0001649. |
| PubMed ID | 29864621 |
| Year | 2018 |
| Title | Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT/mTOR signaling pathway. |
| Drug-related ncRNA | NA |
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